Publications

Research papers:


J. Basso, A. Miranda, J.J. Sousa, A. A. C. C. Pais & C . S. Vitorino. Repurposing drugs for glioblastoma: from bench to bedside. Cancer Letters. doi: 10.1016/j.canlet.2018.04.039 (2018),

J. Basso, A. Miranda, S. C. C. Nunes,T. F. G. G. Cova, J. J. Sousa, C. S. Vitorino & A. A. C. C. Pais, Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors, Gels, DOI: 10.3390/gels403006 (2018),

T. F. G. G. Cova, B. F. Milne , S. C. C. Nunes, A. F. Jorge & A. A. C. C. Pais, Modeling Soft Supramolecular Nanostructures by Molecular Simulations, In Molecular Dynamics, DOI: 10.5772/intechopen.74939 (2018),

T. F. G. G. Cova, D. Murtinho, A. A. C. C. Pais & A. J. M. Valente, Combining Cellulose and Cyclodextrins: Fascinating Designs for Materials and Pharmaceutics, Frontiers in Chemistry, doi: 10.3389/fchem.2018.00271 (2018),

J. Silva, M. Mendes, T. F. G. G. Cova, J.J. Sousa, A. A. C. C. Pais & C . S. Vitorino. Unstructured Formulation Data Analysis for the Optimization of Lipid Nanoparticle Drug Delivery Vehicles. AAPS PharmSciTech. https://doi.org/10.1208/s12249-018-1078-0 (2018),

S. C.C. Nunes, T. F. G. G. Cova, R. S. Dias & Alberto A. C. C. Pais. Adsorption of charged macromolecules upon multicomponent responsive surfaces. Physical Chemistry Chemical Physics, doi: 10.1039/C8CP03383H (2018),

T. F. G. G. Cova, B. F. Milne , S. C. C. Nunes & A. A. C. C. Pais. Drastic Stabilization of Junction Nodes in Supramolecular Structures Based on Host-Guest Complexes. Macromolecules. doi: 10.1021/acs.macromol.8b00154 (2018).

T. F. G. G. Cova, S. M. A. Cruz, A. J.M. Valente, P. E. Abreu, J. M.C. Marques & A. A. C. C. Aggregation of Cyclodextrins: Fundamental Issues and Applications. In Cyclodextrin - A Versatile Ingredient. IntechOpen, doi: 10.5772/intechopen.73532 (2018).

L. Damas, R. M. B. Carrilho, S. C. C. Nunes, A. A. C. C. Pais, L. Kollár, M. Pineiro, M. M. Pereira. A novel Pd-catalysed sequential carbonylation/cyclization approach toward bis-N-heterocycles: rationalization by electronic structure calculations. doi: 10.1098/rsos.181140 (2018).

A. F. Jorge, A. Aviñó, A. A. C. C. Pais, R. Eritja & C. Fàbrega. DNA-based nanoscaffolds as vehicles for 5-fluoro-2′-deoxyuridine oligomers in colorectal cancer therapy. Nanoscale. doi: 10.1039/C7NR08442K (2018).

T. Encarnação, C. T. Arranja, T. F. G. G. Cova, A. A. C. C. Pais, M. G. Campos, A. J. F. N. Sobral & H. D. Burrows. Monitoring oil production for biobased feedstock in the microalga Nannochloropsis sp.: a novel method combining the BODIPY BD-C12 fluorescent probe and simple image processing. Journal of Applied Phycology. doi: 10.1007/s10811-018-1437-y (2018).

M. Mendes, A. Miranda, T. F. G. G. Cova,  L. Gonçalves, A. Almeida, J. J. Sousa, M. L.C. do Vale, E. F. Marques, A. A. C. C. Paisc & C. S. Vitorino. Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma. European Journal of Pharmaceutical Sciences. doi: 10.1016/j.ejps.2018.02.024 (2018).

A. Miranda, T. F. G. G. Cova, J. J. Sousa, C. S. Vitorino & A. A. C. C. Pais. Computational modeling in glioblastoma: from the prediction of blood-brain barrier permeability to the simulation of tumor behavior. Future Med. Chem. https://doi.org/10.4155/fmc-2017-0128. (2017).

T. F. G. G. Cova, S. C. C. Nunes, M. V. D. T. Pinho e Melo & A. A. C. C. Pais. Bambusurils as effective ion caging agents: Does desolvation guide conformation? Chem. Phys. Lett. 672. 89-96, IF: 1.815. doi: https:/ /doi.org/10.1016/j.cplett.2017.01.029. (2017). 

T. F. G. G. Cova, S. C. Nunes & A. A. C. C. Pais. Free-energy patterns in inclusion complexes: the relevance of non-included moieties in the stability constants. Phys. Chem. Chem. Phys. 19. 5209-5221; IF: 4.123. doi:10.1039/C6CP08081B. (2017). 

T. F. G. G. Cova, S. Jarmelo, S. J. Formosinho, J. S. Melo & A. A. C. C. Pais. Seeing is believing: multicriteria evaluation using a graphical reference framework. Evaluation 23. IF: 1.362, 479-494. doi: https://doi.org/10.1177/1356389017733336. (2017). 

T. F. G. G. Cova, A. A. C. C. Pais & S. Melo João. Reconstructing the historical synthesis of mauveine from Perkin and Caro: procedure and details. Sci. Rep. 7. IF: 4.259, 6806. doi:10.1038/s41598-017- 07239-z. (2017). 

T. F. G. G. Cova, A. J. Nunes S. C.C. and Valente, M. V. D. T. Pinho e Melo & A. A. C. C. Pais. Properties and patterns in anion-receptors: A closer look at bambusurils. J. Mol. Liq. IF: 3.648, 242. 640-652. doi:10.1016/j.molliq.2017.07.065. (2017).

R. M. F. Fernandes, Y. Wang, P. B. Tavares, S. C. C. Nunes, A. A. C. C. Pais & E. F. Marques. Critical Role of the Spacer Length of Gemini Surfactants on the Formation of Ionic Liquid Crystals and Thermotropic Behavior. J. Phys. Chem. B 121. IF: 1.362, 10583-10592. doi:10.1021/acs.jpcb.7b08618. (2017). 

M. Mendes, S. C. C. Nunes, J. J. Sousa, A. A. C. C. Pais & C. Vitorino. Expanding Transdermal Delivery with Lipid Nanoparticles: A New Drug-in-NLC-in-Adhesive Design. Mol. Pharm. IF: 4.440. doi:10.1021/acs.molpharmaceut.7b00211. (2017). 

A. Miranda, M. Blanco-Prieto, J. S. Sousa, A. A. C. C. Pais & C. S. Vitorino. Breaching barriers in glioblastoma. Part I: Molecular pathways and novel treatment approaches. Int. J. Pharm. 531. IF: 3.649, 372- 388. doi:10.1016/j.ijpharm.2017.07.056. (2017). 

A. Miranda, M. Blanco-Prieto, J. S. Sousa, A. A. C. C. Pais & C. S. Vitorino. Breaching barriers in glioblastoma. Part II: Targeted drug delivery and lipid nanoparticles. Int. J. Pharm. 531. IF: 3.649, 389-410. doi:10.1016/j.ijpharm.2017.07.049. (2017). 

M. Monteser´ın, H. D. Burrows, A. J. M. Valente, A. A. C. C. Pais & et al. Fluorescence Enhancement of a Cationic Fluorene-Phenylene Conjugated Polyelectrolyte Induced by Nonionic n-Alkyl Polyoxyethylene Surfactants. Langmuir 33. IF: 1.362, 13350-13363. doi:10.1021/ acs.langmuir.7b02818. (2017). 

E. Rieloff, S. C. C. Nunes, A. A. C. C. Pais & M. Skep¨o. Structural Characterization of Bubbles Formed in DNA Melting: A Monte Carlo Simulation Study. ACS Omega 2. 1915-1921. doi:10.1021/acsomega. 7b00323. (2017). 

M. E. Serra, D. Murtinho, Z. N. Rocha, A. S. Pires, J. G. Baptista, A. M. Abrantes, M. Laranjo, J. E. Casalta-Lopes, M. F. Botelho, A. A. Pai, S. C. Nunes, H. D. Burrow & T. Costa. Dibrominated camphoric acid derived salen complexes: Synthesis, characterization and cytotoxic activity. Polyhedron 137. IF: 1.926, 147-156. doi:https://doi.org/10.1016/j.poly.2017.08.038. (2017).

M. Mendes, S. C. C. Nunes, J. J. Sousa, A. A. C. C. Pais & C. Vitorino. Expanding Transdermal Delivery with Lipid Nanoparticles: A New Drug-in-NLC-in-Adhesive Design. Mol. Pharm. IF: 4.440. doi:10.1021/acs.molpharmaceut.7b00211. https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.7b00211> (2017).

E. Rieloff, S. C. C. Nunes, A. A. C. C. Pais & M. Skepo. Structural Characterization of Bubbles Formed in DNA Melting: A Monte Carlo Simulation Study. ACS Omega 2. 1915-1921. doi:10.1021/acsomega.7b00323. <https://dx.doi.org/10.1021/acsomega.7b00323> (2017).

J. G. C. Baptista, S. P. J. Rodrigues, A. F. Y. Matsushita, C. Vitorino, T. M. R. Maria, H. D. Burrows, A. A. C. C. Pais & A. J. M. Valente. Does poly(vinyl alcohol) act as an amphiphilic polymer? An interaction
study with simvastatin. J. Mol. Liq. 222. 287-294; IF: 3.648, Cited by 2. doi:10.1016/j.molliq.2016.07.025.<https://www.sciencedirect.com/science/article/pii/S016773221631282X> (2016).

C. S. de Castro, T. F. G. G. Cova, A. C. C. Pais, D. Pinheiro, C. Nunez, C. Lodeiro & J. S. Seixas de Melo. Probing metal cations with two new Schiff base bischromophoric pyrene based chemo-sensors: Synthesis, photophysics and interactions patterns. Dyes Pigments 134. 601-612; IF: 3.473. doi:10.1016/j.dyepig.2016.08.016. <https://www.sciencedirect.com/science/article/pii/S0143720816303990> (2016).

C. M. C. Filho, M. N. L. Neto, R. S. Teixeira, A. A. C. C. Pais & A. J. M. Valente. Development and optimization of an HPLC-DAD method for quantification of six petroleum hydrocarbon compounds in aqueous samples. J. Liq. Chrom. R. Tech. 39. 837-846. doi:10.1080/10826076 . 2016 . 1274998. <https://www . tandfonline.com/doi/full/10.1080/10826076.2016.1274998> (2016).

M. C. Gaspar, N. Gregoire, J. J. Sousa, A. A. C. C. Pais, I. Lamarche, P. Gobin, J. C. Olivier, S. Marchand & W. Couet. Pulmonary pharmacokinetics of levofloxacin in rats after aerosolization of immediate-release chitosan or sustained-release PLGA microspheres. Eur. J. Pharm. Sci. 93. 184-191; IF: 3.756, Cited by 2. doi:10.1016/j.ejps.2016.08.024. <https://www.ncbi.nlm.nih.gov/pubmed/27531420> (2016).

A. F. Jorge, S. C. C. Nunes, T. F. G. G. Cova & A. A. C. C. Pais. Co-operative action in DNA condensation. Curr. Opin. Colloid Int. Sci. 26. 66-74; IF: 6.136. doi:10.1016/j.cocis.2016.09.014. <https://www.sciencedirect . com / science / article / pii / S1359029416301467>(2016).

S. M. M. Lopes, S. C. C. Nunes, C. C. Carat ̃ao, A. A. C. C. Pais & T. M. V. D. Pinho e Melo. Reactivity of 1-arylnitrosoethylenes towards indole derivatives. Monatsh. Chem. 147. 1565-1573; IF: 1.282, Cited by 1. doi:10.1007/s00706-016-1763-1. <https://link.springer.com/journal/706> (2016).

M. Mendes, H. T. Soares, L. G. Arnaut, J. J. Sousa, A. A. C. C. Pais & C. Vitorino. Can lipid nanoparticles improve intestinal absorption? Int. J. Pharm. 515. 69-83; IF: 3.649, Cited by 1. doi:10.1016/j.ijpharm.2016.09.065. <https://www.ncbi.nlm.nih.gov/pubmed/27667757>(2016).

M. Soares, C. Vitorino, J. Sousa & A. A. Pais. Permeação cutânea: desafios e oportunidades. J. Basic App. Pharm. Sci. 36. 337-348. <https://seer.fcfar.unesp.br/rcfba/index.php/rcfba/article/view/332> (2016).

T. F. G. G. Cova, S. Jarmelo, S. J. Formosinho, J. S. S. de Melo & A. A. C. C. Pais. Unsupervised characterization of research institutions with task-force estimation. J. Inform. 9. 59-68; IF: 2.920, Cited by 2. doi:10.1016/j.joi.2014.11.005. <https://www.sciencedirect.com/science/article/pii/S1751157714001072> (2015).

T. Encarnação, A. A. C. C. Pais, M. G. Campos & H. D. Burrows. Cyanobacteria and microalgae: a renewable source of bioactive compounds and other chemicals. Sci. Prog. 98. 145-168, Cited by 5. doi:10.3184/003685015x14298590596266.<https://www.ncbi.nlm.nih.gov/pubmed/26288917> (2015).

A. Figueiras, S. C. C. Nunes, S. Simões, A. A. C. C. Pais & F. Veiga. Molecular interaction governing solubility and release profiles in supramolecular systems containing fenbufen, pluronics and cyclodextrins. J. Incl. Phenom. Macrocycl. Chem. 81. 395-407; IF: 1.095, Cited by 5. doi:10.1007/s10847- 014- 0466- 7. <https://link.springer.com/article/10.1007/s10847-014-0466-7> (2015).

M. C. Gaspar, J. J. Sousa, A. A. C. C. Pais, O. Cardoso, D. Murtinho, M. E. Serra, F. Tewes & J. C. Olivier. Optimization of levofloxacin loaded crosslinked chitosan microspheres for inhaled aerosol therapy. Eur. J. Pharm. Biopharm. 96. 65-75; IF: 4.159, Cited by 10 .doi:10.1016/j.ejpb.2015.07.010.<https://www.ncbi.nlm.nih.gov/pubmed/26192459> (2015).

A. F. Jorge, R. Roder, P. Kos, R. S. Dias, E. Wagner & A. A. C. C. Pais. Combining polyethylenimine and Fe(III) for mediating pDNA transfection. Biochim. Biophys. Acta 1850. 1325-35; IF: 4.702, Cited by 2. doi:10.1016/j.bbagen.2015.02.007. <https://www.ncbi.nlm.nih.gov/pubmed/25701646> (2015).

S. M. Lopes, C. F. Correia, S. C. Nunes, N. A. Pereira, A. R. Ferreira, E. P. Sousa, C. S. Gomes, J. A. Salvador, A. A. C. C. Pais & T. M. Pinho e Melo. Synthesis of chiral hexacyclic steroids via [8pi+ 2pi] cycloaddition of diazafulvenium methides. Org. Biomol. Chem. 13. 9127-39; IF: 3.564, Cited by 2. doi:10.1039/c5ob01110h. <http: //www.ncbi.nlm.nih.gov/pubmed/26223980> (2015).

J. Marto, L. Gouveia, I. M. Jorge, A. Duarte, L. M. Goncalves, S. M. Silva, F. Antunes, A. A. C. C. Pais, E. Oliveira, A. J. Almeida & H. M. Ribeiro. Starch-based Pickering emulsions for topical drug delivery: A QbD approach. Colloids Surf. B Biointerfaces 135. 183-92; IF: 3.887, Cited by 12. doi:10.1016/j.colsurfb.2015.07.024. <https://www.ncbi.nlm.nih.gov/pubmed/26263210> (2015).

D. Murtinho, Z. N. da Rocha, A. S. Pires, R. P. Jim ́enez, A. M. Abrantes, M. Laranjo, A. C. Mamede, J. E. Casalta-Lopes, M. F. Botelho, A. A. C. C. Pais, S. C. C. Nunes, H. D. Burrows, T. Costa & M. E. Silva Serra. Synthesis, characterization and assessment of the cytotoxic activity of Cu(II), Fe(III) and Mn(III) complexes of camphoric acid-derived salen ligands. Appl. Organomet. Chem. 29. 425-432; IF:2.319, Cited by 3. doi:10.1002/aoc.3309. <https://onlinelibrary. wiley.com/doi/10.1002/aoc.3309/abstract> (2015).

S. C. Nunes, M. Skepo & A. A. C. C. Pais. Confined polyelectrolytes: The complexity of a simple system. J. Comput. Chem. 36. 1579-86; IF: 3.229, Cited by 2. doi:10.1002/jcc.23969. <https://www.ncbi.nlm.nih.gov/pubmed/26096545> (2015).

M. C. Simoes, J. J. Sousa & A. A. C. C. Pais. Skin cancer and new treatment perspectives: a review. Cancer Lett. 357. 8-42; IF: 6.375, Cited by 48. doi:10.1016/j.canlet.2014.11.001. <https://www.ncbi.nlm.nih.gov/pubmed/25444899> (2015).

M. J. Tapia, M. Monteserin, H. D. Burrows, J. A. Almeida, A. A. C. C. Pais, J. Pina, J. S. Seixas de Melo, S. Jarmelo & J. Estelrich. From molecular modelling to photophysics of neutral oligo- and polyfluore-
nes incorporated into phospholipid bilayers. Soft Matter 11. 303-17; IF: 3.889, Cited by 3. doi:10.1039/c4sm02145b. <https://www.ncbi.nlm. nih.gov/pubmed/25411076> (2015).

R. S. Teixeira, T. F. Cova, S. M. Silva, R. Oliveira, M. L. do Vale, E. F. Marques, A. A. C. C. Pais & F. J. Veiga. Novel serine-based gemini surfactants as chemical permeation enhancers of local anesthetics:
A comprehensive study on structure-activity relationships, molecular dynamics and dermal delivery. Eur. J. Pharm. Biopharm. 93. 205-13; IF: 4.159, Cited by 1. doi:10 . 1016 / j . ejpb . 2015 . 02 . 024. <https://www.ncbi.nlm.nih.gov/pubmed/25748796> (2015).

C. Vitorino, J. J. Sousa & A. A. C. C. Pais. Overcoming the skin permeation barrier: challenges and opportunities. Curr. Pharm. Des. 21. 2698-2712; IF: 2.611, Cited by 4. doi:10.2174/1381612821666150428124053. <https://www.eurekaselect.com/130754/article> (2015).

A. F. Jorge, R. F. Pereira, S. C. Nunes, A. J. Valente, R. S. Dias & A. A. C. C. Pais. Interpreting the rich behavior of ternary DNA-PEI-Fe(III) complexes. Biomacromolecules 15. 478-91; IF: 5.246, Cited by 10. doi:10.1021/bm4013716. <https://www.ncbi.nlm.nih.gov/pubmed/24460059> (2014).

A. C. Lopes, T. F. Cova, A. A. C. C. Pais, J. L. Pereira, B. Colaço & A. M. Cabrita. Improving discrimination in the grading of rat mammary tumors using two-dimensional mapping of histopathological observations. Exp. Toxicol. Pathol. 66. 73-80; IF: 1.975, Cited by 2. doi:10.1016/j.etp.2013.09.001. <https://www.ncbi.nlm.nih.gov/pubmed/24168877> (2014).

S. C. Nunes, S. M. Lopes, C. S. Gomes, A. Lemos, A. A. C. C. Pais & E. M. T. M. Pinho. Reactions of nitrosoalkenes with dipyrromethanes and pyrroles: insight into the mechanistic pathway. J. Org. Chem. 79. 10456-65; IF: 4.849, Cited by 9. doi:10.1021/jo502095k. <https://www.ncbi.nlm.nih.gov/pubmed/25310009> (2014).

A. R. Peixoto A. F. amd Abreu, A. R. Almeida, A. Neves, P. E. Abreu, M. J. S. M. Moreno, J. C. Bayon, A. A. C. C. Pais & M. M. Pereira. BINOL-Based Ditopic Diphosphite Ligands-Synthesis, Evaluation and Regioselectivity Optimization of Catalytic Hydroformylation by 2^3 Factorial Design. Curr. Org. Synth. 11. 301-309; IF: 1.917, Cited by 4. doi:10.2174/15701794113106660072. <https://www.eurekaselect.
com/115297> (2014).

M. Pineiro, B. F. O. Nascimento, A. M. d. Gonsalves, S. C. C. Nunes & A. A. C. C. Pais. On the microwave-assisted synthesis and oxidation of biginelli compounds: Comparative study of dihydropyrimidinones and thiones oxidation. Curr. Microwave Chem. 1. 119-134. doi:10.2174/2213335601666140422225203.<https://www.eurekaselect.com/121725> (2014).

R. S. Teixeira, T. F. Cova, S. M. Silva, R. Oliveira, M. J. Araujo, E. F. Marques, A. A. C. C. Pais & F. J. Veiga. Lysine-based surfactants as chemical permeation enhancers for dermal delivery of local anesthetics. Int. J. Pharm. 474. 212-22; IF: 3.649, Cited by 6. doi:10.1016/j.ijpharm.2014.08.002. <https://www.ncbi.nlm.nih.gov/pubmed/ 25108047> (2014).

C. Vitorino, A. Almeida, J. Sousa, I. Lamarche, P. Gobin, S. Marchand, W. Couet, J. C. Olivier & A. A. C. C. Pais. Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: in vitro vs. in vivo studies. Eur. J. Pharm. Biopharm. 86. doi:10.1016/j.ejpb.2013.12.004. <https://www.ncbi.nlm.nih.gov/pubmed/24333401> (2014).

R. Amaral, J. C. Pereira, A. A. C. C. Pais & L. M. Santos. Is axenicity crucial to cryopreserve microalgae? Cryobiology 67. 312-20; IF: 1.920, Cited by 5. doi:10.1016/j.cryobiol.2013.09.006. <https://www.ncbi.nlm.nih.gov/pubmed/24055827> (2013).

T. F. Cova, J. L. Pereira & A. A. C. C. Pais. Is standard multivariate analysis sufficient in clinical and epidemiological studies? J. Biomed. Inform. 46. 75-86; IF: 2.753, Cited by 5. doi:10.1016/j.jbi.2012.09.
005. <https://www.ncbi.nlm.nih.gov/pubmed/23026231> (2013). 

M. C. Gaspar, W. Couet, J. C. Olivier, A. A. C. C. Pais & J. J. Sousa. Pseudomonas aeruginosa infection in cystic fibrosis lung disease and new perspectives of treatment: a review. Eur. J. Clin. Microbiol. Infect. Dis. 32. 1231-52; IF: 2.727, Cited by 60. doi:10.1007/s10096-013-1876-y. <https://www.ncbi.nlm.nih.gov/pubmed/23619573> (2013).

A. F. Jorge, M. C. Mor ́an, M. P. Vinardell, J. C. Pereira, R. S. Dias & A. A. C. C. Pais. Ternary complexes DNA-polyethylenimine-Fe(iii) with linear and branched polycations: implications on condensation,
size, charge and in vitro biocompatibility. Soft Matter 9. 10799; IF: 3.889, Cited by 5. doi:10.1039/c3sm51616d. <https://pubs.rsc.org/en/content/articlehtml/2013/sm/c3sm51616d> (2013).

A. J. Lopes Jesus, J. A. S. Almeida, A. A. C. C. Pais & J. S. Redinha. Molecular dynamics and quantum chemical approaches in the study of the hydration of protonated cyclohexyldiamines. Mol. Phys. 112. 173-181; IF: 1.870, Cited by 1. doi:10 . 1080 / 00268976 . 2013 . 805848.<http : / / www . tandfonline . com / doi / full / 10 . 1080 / 00268976.2013.805848> (2013).

S. C. Nunes, T. F. Cova & A. A. C. C. Pais. A new perspective on correlated polyelectrolyte adsorption: positioning, conformation, and patterns. J. Chem. Phys. 139. 054906; IF: 2.965, Cited by 8. doi:10.1063/1.4817338. <https://www.ncbi.nlm.nih.gov/pubmed/23927283>(2013).

S. C. Nunes, P. Pinto & A. A. C. C. Pais. Nonrandom adsorption of polyelectrolyte chains on finite regularly charged surfaces. J. Comput.Chem. 34. 1198-209; IF: 3.229, Cited by 2. doi:10.1002/jcc.23238. <https://www.ncbi.nlm.nih.gov/pubmed/23386422> (2013).

S. M. Silva, J. J. Sousa, E. F. Marques, A. A. C. C. Pais & B. B. Michniak-Kohn. Structure activity relationships in alkylammonium C12-gemini surfactants used as dermal permeation enhancers. AAPS J. 15. 1119-27; IF: 3.423, Cited by 11. doi:10.1208/s12248-013-9518-y. <https://www.ncbi.nlm.nih.gov/pubmed/23959685> (2013).

C. Vitorino, J. Almeida, L. M. Goncalves, A. J. Almeida, J. J. Sousa & A. A. C. C. Pais. Co-encapsulating nanostructured lipid carriers for transdermal application: from experimental design to the molecular detail. J. Control. Release 167. 301-14; IF: 7.441, Cited by 48. doi:10. 1016/j.jconrel.2013.02.011. <https://www.ncbi.nlm.nih.gov/ pubmed/23454133> (2013).

C. Vitorino, J. J. Sousa & A. A. C. C. Pais. A rapid reversed-phase HPLC method for the simultaneous analysis of olanzapine and simvastatin in dual nanostructured lipid carriers. Anal. Met. 5. 5058, IF:1.900, Cited by 7. doi:10.1039/c3ay40757h. <https://pubs.rsc.org/en/content/articlelanding/2013/ay/c3ay40757h#!divAbstract> (2013).

C. Vitorino, L. Alves, F. E. Antunes, J. J. Sousa & A. A. C. C. Pais. Design of a dual nanostructured lipid carrier formulation based on physicochemical, rheological, and mechanical properties. J. Nanopart. Res. 15. 1993; IF: 2.020, Cited by 7. doi:10.1007/s11051-013-1993-7. <https:// link.springer.com/article/10.1007/s11051-013-1993-7> (2013).

H. D. Burrows, D. Costa, M. L. Ramos, G. Miguel Mda, M. H. Teixeira, A. A. C. C. Pais, A. J. Valente, M. Bastos & G. Bai. Does cation dehydration drive the binding of metal ions to polyelectrolytes in water? What we can learn from the behaviour of aluminium(III) and chromium(III). Phys. Chem. Chem. Phys. 14. 7950-3; IF: 4.123, Cited by 7. doi:10.1039/c2cp40480j. <https://www.ncbi.nlm.nih.gov/pubmed/22569828> (2012).

T. F. G. G. Cova, A. A. C. C. Pais & S. J. Formosinho. Iberian universities: a characterisation from ESI rankings. Scientometrics 94. 1239-1251; 2.147, Cited by 6. doi:10.1007/s11192- 012- 0792- 8. <https://link.springer.com/article/10.1007/s11192-012-0792-8> (2012).

R. S. Dias & A. A. C. C. Pais. Effect of the architecture on polyelectrolyte adsorption and condensation at responsive surfaces. J. Phys. Chem. B 116. 9246-54; IF: 3.177, Cited by 7. doi:10.1021/jp303540q. <https://www.ncbi.nlm.nih.gov/pubmed/22731811> (2012).

T. Encarnação, H. D. Burrows, A. A. C. C. Pais, M. G. Campos & A. Kremer. Effect of N and P on the Uptake of Magnesium and Iron and on the Production of Carotenoids and Chlorophyll by the Microalgae Nannochloropsis sp. J. Agr. Sci. Tech. 2. 824; IF: 0.813 (2012).

A. F. Jorge, R. S. Dias & A. A. C. C. C. Pais. Enhanced condensation and facilitated release of DNA using mixed cationic agents: a combined experimental and Monte Carlo study. Biomacromolecules 13. 3151-61; IF: 5.246, Cited by 16. doi:10.1021/bm300934p. <https://www.ncbi.nlm.nih.gov/pubmed/22920592> (2012).

J. M. Marques, A. A. C. C. Pais & P. E. Abreu. On the use of big-bang method to generate low-energy structures of atomic clusters modelled with pair potentials of different ranges. J. Comput. Chem. 33. 442-52; IF: 3.229, Cited by 15. doi:10.1002/jcc.21987. <https://www.ncbi.nlm.nih.gov/pubmed/22131287> (2012).

S. C. C. Nunes, J. A. S. Almeida, R. S. Dias & A. A. C. C. Pais. The role of excluded volume and electrostatics from coarse-grain modeling of the interaction of gemini surfactants with like-charged membranes. Mol. Phys. 111. 123-134; IF: 1.870, Cited by 1. doi:10.1080/00268976.2012.707339. <https://www.tandfonline.com/doi/abs/10.1080/00268976.2012.707339> (2012).

P. Pereira, A. F. Jorge, R. Martins, A. A. C. C. Pais, F. Sousa & A. Figueiras. Characterization of polyplexes involving small RNA. J. Colloid Interface Sci. 387. 84-94; IF: 4.233, Cited by 16. doi:10.1016/j.jcis.2012.07.088. <https://www.ncbi.nlm.nih.gov/pubmed/22980740> (2012).

C. I. Ramos, M. G. Santana-Marques, A. J. Ferrer-Correia, J. F. Barata, A. C. Tome, M. G. Neves, J. A. Cavaleiro, P. E. Abreu, M. M. Pereira & A. A. C. C. Pais. Differentiation of aminomethyl corrole iso-
mers by mass spectrometry. J. Mass. Spectrom. 47. 516-22; IF: 2.422, Cited by 7. doi:10.1002/jms.2973. <https://www.ncbi.nlm.nih.gov/ pubmed/22689628> (2012).

B. S. Santos, S. C. C. Nunes, A. A. C. C. Pais & T. M. V. D. Pinho e Melo. Chiral spiro-β-lactams from 6-diazopenicillanates. Tetrahedron 68. 3729-3737; IF: 2.651, Cited by 9. doi:10.1016/j.tet.2012.03. 022. <https://www.sciencedirect.com/science/article/pii/S0040402012003407> (2012).

S. M. Silva, L. Hu, J. J. Sousa, A. A. C. C. Pais & B. B. Michniak-Kohn. A combination of nonionic surfactants and iontophoresis to enhance the transdermal drug delivery of ondansetron HCl and diltiazem HCl. Eur. J. Pharm. Biopharm. 80. 663-73; IF: 4.159, Cited by 23. doi:10.1016/j.ejpb.2011.11.010. <https://www.ncbi.nlm.nih.gov/pubmed/22137964> (2012).

J. A. Almeida, H. Faneca, R. A. Carvalho, E. F. Marques & A. A. C. C. Pais. Dicationic alkylammonium bromide gemini surfactants. Membrane perturbation and skin irritation. PLoS One 6. e26965; IF: 3.057, Cited by 19. doi:10.1371/journal.pone.0026965. <https://www.ncbi.nlm.nih.gov/pubmed/22102870> (2011).

J. A. Almeida, S. P. Pinto, Y. Wang, E. F. Marques & A. A. C. C. Pais. Structure and order of DODAB bilayers modulated by dicationic gemini surfactants. Phys. Chem. Chem. Phys. 13. 13772-82; IF: 4.123,
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A. M. Cardoso, H. Faneca, J. A. Almeida, A. A. C. C. Pais, E. F. Mar- ques, M. C. de Lima & A. S. Jurado. Gemini surfactant dimethylene-1,2-bis(tetradecyldimethylammonium bromide)-based gene vectors: a bi-ophysical approach to transfection efficiency. Biochim. Biophys. Acta 1808. 341-51; IF: 4.702, Cited by 36. doi:10.1016/j.bbamem.2010.09. 026. <https://www.ncbi.nlm.nih.gov/pubmed/20937247> (2011).

R. S. Dias, P. Linse & A. A. C. C. Pais. Stepwise disproportionation in polyelectrolyte complexes. J. Comput. Chem. 32. 2697-707; IF: 3.229, Cited by 22. doi:10.1002/jcc.21851. <https://www.ncbi.nlm.nih.
gov/pubmed/21671241> (2011).

S. M. C. Silva, F. E. Antunes, J. J. S. Sousa, A. J. M. Valente & A. A. C. C. Pais. New insights on the interaction between hydroxypropylmethyl cellulose and sodium dodecyl sulfate. Carbohydr. Polym.
86. 35-44; IF: 4.811, Cited by 24. doi:10.1016/j.carbpol.2011.03.053. <https://www.sciencedirect.com/science/article/pii/S0144861711002384> (2011).

C. Vitorino, F. A. Carvalho, A. J. Almeida, J. J. Sousa & A. A. C. C. Pais. The size of solid lipid nanoparticles: an interpretation from experimental design. Colloids Surf. B Biointerfaces 84. 117-30; IF: 3.887, Cited by 74. doi:10.1016/j.colsurfb.2010.12.024. <https://www.ncbi.nlm.nih.gov/pubmed/21242064> (2011).

P. E. Abreu, A. A. C. C. Pais & S. J. Formosinho. The role of transition state bond-order on structure-reactivity relationships: the case of pericyclic and pseudo-pericyclic reactions. ARKIVOC 92. 104; IF: 1.031. doi:10.3998/ark.5550190.0011.510. <https://quod.lib.umich. edu/a/ark/5550190.0011.510/--role-of-transiton-state-bond-order-on-structure-reactivity?view=text&seq=1&size=175>(2010).

J. A. S. Almeida, M. C. Mor ́an, M. R. Infante & A. A. C. C. Pais. Interaction of arginine-based cationic surfactants with lipid membranes. An experimental and molecular simulation study. ARKIVOC. 34-50; IF: 1.031, Cited by 7. doi:10.3998/ark.5550190.0011 .505. <http : / / quod . lib . umich . edu / a / ark / 5550190.0011.505/1/--interaction-of-arginine-based-cationic-surfactants-with?page=root;size=125;view=text> (2010).

J. A. Almeida, E. F. Marques, A. S. Jurado & A. A. C. C. Pais. The effect of cationic gemini surfactants upon lipid membranes. An experimental and molecular dynamics simulation study. Phys. Chem. Chem. Phys. 12. 14462-14476; IF: 4.123, Cited by 29. doi:10.1039/C0CP00950D.<https://pubs.rsc.org/en/Content/ArticleLanding/2010/CP/c0cp00950d#!divAbstract> (2010).

A. L. Cardoso, A. M. Beja, M. R. Silva, J. M. de los Santos, F. Palacios, P. E. Abreu, A. A. C. C. Pais & T. M. V. D. Pinho e Melo. Stereoselective formation of tertiary and quaternary carbon centers via inverse
conjugate addition of carbonucleophiles to allenic esters. Tetrahedron 66. 7720-7725; IF: 2.651, Cited by 9. doi:10.1016/j.tet.2010.08. 002. <https://www.sciencedirect.com/science/article/pii/S0040402010011725> (2010).

D. Costa, A. J. M. Valente, A. A. C. C. Pais, M. G. Miguel & B. Lindman. Cross-linked DNA gels: Disruption and release properties. Colloids Surf. A Physicochem. Eng. Asp. 354. 28-33; IF: 2.714, Cited by 17. doi:10.1016/j.colsurfa.2009.08.009. <https://www.sciencedirect.com/science/article/pii/S0927775709004956> (2010).

F. O. Costa-Balogh, E. Sparr, J. J. Sousa & A. A. C. C. Pais. Drug release from lipid liquid crystalline phases: relation with phase behavior. Drug. Dev. Ind. Pharm. 36. 470-81; IF: 2.295, Cited by 21. doi:10.3109/03639040903261997. <https://www.ncbi.nlm.nih.gov/pubmed/19848561> (2010).

R. S. Dias & A. A. C. C. Pais. Polyelectrolyte condensation in bulk, at surfaces, and under confinement. Adv. Colloid Interface Sci. 158. 48-62; IF: 7.223, Cited by 22. doi:10.1016/j.cis.2010.02.007. <https://www.ncbi.nlm.nih.gov/pubmed/20347064> (2010).

A. Figueiras, J. M. Sarragu ̧ca, A. A. C. C. Pais, R. A. Carvalho & F. J. B. Veiga. The role of L-arginine in inclusion complexes of omeprazole with cyclodextrins. AAPS PharmSciTech 11. 233-40; IF: 1.954, Cited by 12. doi:10.1208/s12249-009-9375-2. <https://www.ncbi.nlm.nih.gov/pubmed/20135244> (2010).

A. Figueiras, A. A. C. C. Pais & F. J. B. Veiga. A comprehensive development strategy in buccal drug delivery. AAPS PharmSciTech 11. 1703-1712; IF: 1.954, Cited by 5. doi:10.1208/s12249- 010- 9546- 1. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011081/> (2010).

A. F. Jorge, R. S. Dias, J. C. Pereira & A. A. C. C. Pais. DNA condensation by pH-responsive polycations. Biomacromolecules 11. 2399-2406; IF: 5.246, Cited by 35. doi:10.1021/bm100565r. <https://pubs.acs.org/doi/abs/10.1021/bm100565r> (2010).

J. M. Marques, A. A. C. C. Pais & P. E. Abreu. Generation and characterization of low-energy structures in atomic clusters. J. Comput. Chem. 31. 1495-503; IF: 3.229, Cited by 15. doi:10.1002/jcc.21436. <https://www.ncbi.nlm.nih.gov/pubmed/19882729> (2010).

M. E. Serra, D. Murtinho, A. Goth, A. M. Rocha Gonsalves, P. E. Abreu & A. A. C. C. Pais. Ultrasound-mediated synthesis of camphoric acid-based chiral salens for the enantioselective trimethylsilylcyanation of aldehydes. Chirality 22. 425-31; IF: 1.956, Cited by 16. doi:10.1002/chir.20758.  <https://www.ncbi.nlm.nih.gov/pubmed/19603482> (2010).

M. J. Tapia, M. Monteser ́ın, A. Costoyas, H. D. Burrows, A. T. Marques, A. A. C. C. Pais, A. J. M. Valente, R. Mallavia, U. Scherf, A. Pinazo, L. P ́erez & M. C. Mor ́an. Effects of commercial non-ionic alkyl oxyethylene and ionic biocompatible arginine-based surfactants on the photophysical behaviour of several poly(fluorene-1,4-phenylene)s. J. Mol. Liq. 156. 18-27; IF: 3.648, Cited by 10. doi:10.1016/j.molliq.2010.05.026.<https://www.sciencedirect.com/science/article/pii/S0167732210001881> (2010).

M. I. S. Ver ́ıssimo, A. A. C. C. Pais & M. T. S. R. Gomes. Following HPMC gelation with a piezoelectric quartz crystal. Carbohydr. Polym. 82. 363-369; IF: 4.811, Cited by 14. doi:10.1016/j.carbpol.2010. 04.064. <https://www.sciencedirect.com/science/article/pii/S0144861710003486> (2010).

J. A. S. Almeida, A. A. C. C. Pais & S. J. Formosinho. Science indicators and science patterns in Europe. J. Inform. 3. 134-142; IF: 2.920, Cited by 34. doi:10 . 1016 / j . joi . 2009 . 01 . 001. <http : / / www.sciencedirect.com/science/article/pii/S175115770900008X> (2009).

H. D. Burrows, M. J. Tapia, S. M. Fonseca, S. Pradhan, U. Scherf, C. L. Silva, A. A. C. C. Pais, A. J. M. Valente, K. Schill ́en & V. Alfredsson. Solubilization of Poly1, 4-phenylene-[9, 9-bis (4-phenoxy-butylsulfonate)] fluorene-2, 7-diyl in Water by Nonionic Amphiphiles. Langmuir 25. 5545-5556; IF: 3.833, Cited by 35. doi:10 . 1021 / la8042044. <https://pubs.acs.org/doi/abs/10.1021/la8042044> (2009).

A. F. Jorge, J. M. Sarragu ̧ca, R. S. Dias & A. A. C. C. Pais. Polyelectrolyte compaction by pH-responsive agents. Phys. Chem. Chem. Phys. 11. 10890-8; IF: 4.123, Cited by 20. doi:10.1039/b914159f. <https://www.ncbi.nlm.nih.gov/pubmed/19924323> (2009).

M. C. Moran, A. A. C. C. Pais, A. Ramalho, M. G. Miguel & B. Lindman. Mixed Protein Carriers for Modulating DNA Release. Langmuir 25. 10263-10270, IF: 3.833, Cited by 22. doi:10.1021/la901071v.
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M. F. Pinto, M. C. Mor ́an, M. G. Miguel, B. Lindman, A. S. Jurado & A. A. Pais. Controlling the morphology in DNA condensation and precipitation. Biomacromolecules 10. 1319-1323; IF: 5.246, Cited by 23. doi:10.1021/bm900211j. <https://pubs.acs.org/doi/abs/10.1021/bm900211j> (2009).

J. M. G. Sarragu ̧ca, A. A. C. C. Pais & P. Linse. Influence of droplet properties on the formation of microemulsion-ABA-triblock copolymer networks. Soft Matter 5. 140-147; IF: 3.889, Cited by 3. doi:10.1039/b809459d. <https://pubs.rsc.org/en/Content/ArticleLanding/2009/SM/b809459d#!divAbstract> (2009).

H. D. Burrows, S. M. Fonseca, C. L. Silva, A. A. C. C. Pais, M. J. Tapia, S. Pradhan & U. Scherf. Aggregation of the hairy rod conjugated polyelectrolyte poly1,4-phenylene-[9,9-bis(4-phenoxybutylsulfonate)]fluorene-2,7-diyl in aqueous solution: an experimental and molecular modelling study. Phys. Chem. Chem. Phys. 10. 4420-8; IF: 4.123, Cited by 43. doi:10.1039/b800773j. <https://www.ncbi.nlm.nih.gov/pubmed/18654681> (2008).

F. O. Costa-Balogh, E. Sparr, J. J. S. Sousa & A. A. C. C. Pais. Drug Release and Skin Permeation from Lipid Liquid Crystalline Phases. Progr. Colloid Polym. Sci. 135. 119-129; IF: 1.890, Cited by 5. doi:10.1007/2882_2008_097. <https://link.springer.com/chapter/10.1007/2882_2008_097> (2008).

A. Figueiras, J. M. G. Sarragu ̧ca, A. A. C. C. Pais, J. F. Veiga & R. A. Carvalho. New insight into the discrimination between omeprazole enantiomers by cyclodextrins in aqueous solution. J. Incl. Phenom. Macrocycl. Chem. 62. 345-351; IF: 1.095, Cited by 3. doi:10.1007/s10847-008-9477-6. <https://link.springer.com/article/10.1007%5C%2Fs10847-008-9477-6> (2008).

S. Gaweda, M. C. Moran, A. A. C. C. Pais, R. S. Dias, K. Schillen, B. Lindman & M. G. Miguel. Cationic agents for DNA compaction. J. Colloid Interface Sci. 323. 75-83; IF: 4.233, Cited by 37. doi:10.1016/
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T. M. V. D. Pinho e Melo, A. L. Cardoso, F. Palacios, J. M. de los Santos, A. A. C. C. Pais, P. E. Abreu, J. A. Paix ̃ao, A. M. Beja & M. Ramos Silva. New approach to exclusive formation of both enantiomers of β-amino acid derivatives. Tetrahedron 64. 8141-8148; IF: 2.651, Cited by 8. doi:10.1016/j.tet.2008.06.053.<https://www.sciencedirect.com/science/article/pii/S004040200801154X> (2008).

J. M. G. Sarragu ̧ca, A. A. C. C. Pais & P. Linse. Structure of microemulsion-ABA triblock copolymer networks. Langmuir 24. 11153-11163; IF: 3.833, Cited by 5. doi:10.1021/la801658k. <https://www.ncbi.nlm.nih.gov/pubmed/18729531> (2008).

C. L. Silva, J. C. Pereira, A. Ramalho, A. A. C. C. Pais & J. J. S. Sousa. Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization. J. Membr. Sci. 320. 268-279; IF: 6.035, Cited by 75. doi:10.1016/j.memsci. 008 . 04 .011. <http : / / www . sciencedirect.com/science/article/pii/S0376738808003190> (2008).

S. M. Silva, F. V. Pinto, F. E. Antunes, M. G. Miguel, J. J. Sousa & A. A. C. C. Pais. Aggregation and gelation in hydroxypropylmethyl cellulose aqueous solutions. J. Colloid Interface Sci. 327. 333-40; IF:
4.233, Cited by 69. doi:10.1016/j.jcis.2008.08.056. <https://www. ncbi.nlm.nih.gov/pubmed/18804777> (2008).

M. I. S. Ver ́ıssimo, A. A. C. C. Pais, J. A. B. P. Oliveira & M. T. S. R. Gomes. Use of an acoustic wave  sensor to follow lead absorption byporcine skin. Sens. Actuators B Chem. 128. 450-454; IF: 5.401,  Cited by 3. doi:10.1016/j.snb.2007.07.011. <https://www.sciencedirect. com/science/article/pii/S0925400507004686> (2008).

J. A. S. Almeida, L. M. S. Barbosa, A. A. C. C. Pais & S. J. Formosinho. Improving hierarchical cluster analysis: A new method with outlier detection and automatic clustering. Chemometr. Intell. Lab. Syst. 87. 208-217; IF: 2.303, Cited by 139. doi:10.1016/j.chemolab.2007.01.005. <https://www.sciencedirect.com/science/article/pii/S0169743907000068> (2007).

H. D. Burrows, M. J. Tapia, C. L. Silva, A. A. C. C. Pais, S. M. Fonseca, J. Pina, J. S. de Melo, Y. Wang, E. F. Marques, M. Knaapila, A. P. Monkman, V. M. Garamus, S. Pradhan & U. Scherf. Interplay of electrostatic and hydrophobic effects with binding of cationic gemini surfactants and a conjugated polyanion: experimental and molecular modeling studies. J. Phys. Chem. B 111. 4401-10; IF: 3.177, Cited by 60. doi:10.1021/jp070100s.<https://www.ncbi.nlm.nih.gov/pubmed/17425360> (2007).

A. Figueiras, J. M. Sarragu ̧ca, R. A. Carvalho, A. A. C. C. Pais & F. J. Veiga. Interaction of omeprazole with a methylated derivative of beta-cyclodextrin: phase solubility, NMR spectroscopy and molecular
simulation. Pharm. Res. 24. 377-89; IF: 3.260, Cited by 59. doi:10.1007 / s11095 - 006 - 9161 - 8. <https://www.ncbi.nlm.nih.gov/pubmed/17177111> (2007).

R. A. Izquierdo, C. M. Barros, M. G. Santana-Marques, A. J. Correia, E. M. Silva, F. Giuntini, M. A. Faustino, J. P. Tome, A. C. Tome, A. M. Silva, G. P. Neves, J. A. Cavaleiro, A. F. Peixoto, M. M. Pereira & A. A. C. C. Pais. Characterization of isomeric cationic porphyrins with beta-pyrrolic substituents by electrospray mass spectrometry: the singular behavior of a potential virus photoinactivator. J. Am. Soc.
Mass. Spectrom. 18. 218-25; IF: 2.786, Cited by 12. doi:10.1016/j.jasms . 2006 . 09 . 010. <http : / / www . ncbi.nlm.nih.gov/pubmed/17070697> (2007).

A. F. Peixoto, M. M. Pereira & A. A. C. C. Pais. Maximization of regioselectivity in hydroformylation of vinyl-aromatics using simple factorial design. J. Mol. Catal. A: Chem. 267. 234-240; IF: 4.211, Cited by 5. doi:10.1016/j.molcata.2006.11.040.  <https://www.sciencedirect.com/science/article/pii/S1381116906013926>(2007).

A. Ramalho, C. L. Silva, A. A. C. C. Pais & J. J. S. Sousa. In vivo friction study of human skin: Influence of moisturizers on different anatomical sites. Wear 263. 1044-1049; IF: 2.531, Cited by 45. doi:10.1016 / j . wear . 2006 . 11 . 051. <https://www.sciencedirect.com/science/article/pii/S0043164807004267> (2007).

F. Rubio, F. Garc ́ıa, H. D. Burrows, A. A. C. C. Pais, A. J. M. Valente, M. J. Tapia & J. M. Garcia.  Aqueous solution and solid state interactionsof lanthanide ions with a methacrylic ester polymer bearing pendant 15-crown-5 moieties. J. Polym. Sci. A 45. 1788-1799; IF: 3.113, Cited by 11. doi:10.1002/pola.21946. <https://onlinelibrary.wiley.com/doi/10.1002/pola.21946/full> (2007).

C. L. Silva, D. Topgaard, V. Kocherbitov, J. J. Sousa, A. A. C. C. Pais & E. Sparr. Stratum corneum hydration: phase transformations and mobility in stratum corneum, extracted lipids and isolated corneocytes. Biochim. Biophys. Acta 1768. 2647-59; IF: 4.702, Cited by 68. doi:10.1016/j.bbamem.2007.05.028. <https://www.ncbi.nlm.nih.gov/pubmed/17927949> (2007).

M. Barroso, J. C. Pereira, A. A. C. C. Pais, L. G. Arnaut & S. J. Formosinho. Molecular factor analysis in atom-transfer reactions. Mol. Phys. 104. 731-743; IF: 1.870, Cited by 4. doi:10.1080/00268970500417085. <https://www.tandfonline.com/doi/abs/10. 1080/00268970500417085> (2006).

P. J. S. Gomes, C. M. Nunes, A. A. C. C. Pais, T. M. V. D. Pinho e Melo & L. G. Arnaut. 1,3-Dipolar cycloaddition of azomethineylides generated from aziridines in supercritical carbon dioxide. Tetrahedron Lett. 47. 5475-5479; IF: 2.193, Cited by 34. doi:10.1016/j.tetlet. 2006.05.179. <https://www.sciencedirect.com/science/article/pii/S0040403906011348> (2006).

A. Ramalho, C. L. Silva, A. A. C. C. Pais & J. J. S. Sousa. In vivo friction study of human palmoplantar skin against glass. J. Tribol. 25. 14, IF: 1.521, Cited by 12 (2006).

J. M. Sarragu ̧ca, R. S. Dias & A. A. C. C. Pais. Coil-globule coexistence and compaction of DNA chains. J. Biol. Phys. 32. 421-34; IF: 1.241, Cited by 13. doi:10.1007/s10867-006-9026-8. <https://www.ncbi.nlm.nih.gov/pubmed/19669448> (2006).

J. M. Sarragu ̧ca & A. A. C. Pais. Polyelectrolytes in solutions with multivalent salt. Effects of flexibility and contour length. Phys. Chem. Chem. Phys. 8. 4233-41; IF: 4.123, Cited by 22. doi:10.1039/b606087k. <https://www.ncbi.nlm.nih.gov/pubmed/16971992> (2006).

C. L. Silva, S. C. Nunes, M. E. Eusebio, A. A. C. C. Pais & J. J. Sousa. Thermal behaviour of human stratum corneum. A differential scanning calorimetry study at high scanning rates. Skin Pharmacol. Physiol. 19. 132-9; IF: 2.756, Cited by 29. doi:10.1159/000092593. <https://www.ncbi.nlm.nih.gov/pubmed/16612140> (2006). C. L. Silva, S. C. Nunes, M. E. Eusebio, J. J. Sousa & A. A. C. C. Pais. Study of human stratum corneum and extracted lipids by thermomicroscopy and DSC. Chem. Phys. Lip. 140. 36-47; IF: 3.361, Cited by
37. doi:10.1016/j.chemphyslip.2006.01.004. <https://www.ncbi. nlm.nih.gov/pubmed/16480966> (2006).

R. S. Dias, A. A. C. C. Pais, P. Linse, M. G. Miguel & B. Lindman. Polyion adsorption onto catanionic surfaces. A Monte Carlo study. J. Phys. Chem. B 109. 11781-11788; IF: 3.177, Cited by 50. doi:10.1021/

A. F. Peixoto, M. M. Pereira, A. F. Sousa, A. A. C. C. Pais, M. G. P. M. S. Neves, A. M. S. Silva & J. A. S. Cavaleiro. Improving regioselectivity in the rhodium catalyzed hydroformylation of protoporphyrin-IX and chlorophyll a derivatives. J. Mol. Catal. A: Chem. 235. 185-193; IF: 4.211, Cited by 8. doi:10.1016/j.molcata. 2005.04.008. <https://www.sciencedirect.com/science/article/pii/S1381116905002396> (2005).

A. F. Sousa, A. A. C. C. Pais & P. Linse Polymer distribution in connected spherical domains. J. Chem. Phys. 122. 214902; IF: 2.965, Cited by 8. doi:10.1063/1.1904592. <https://www.ncbi.nlm.nih.gov/pubmed/15974785> (2005).

F. O. Costa, A. A. C. C. Pais & J. J. S. Sousa. Analysis of formulation effects in the dissolution of ibuprofen pellets. Int. J. Pharm. 270. 9-19; IF: 3.649, Cited by 37. doi:10.1016/j.ijpharm.2003.10.002. <https://www.sciencedirect.com/science/article/pii/S0378517303005556> (2004).

R. S. Dias, A. A. C. C. Pais, M. G. Miguel & B. Lindman. DNA and surfactants in bulk and at interfaces. Colloids Surf. A Physicochem. Eng. Asp. 250. 115-131; IF: 2.714, Cited by 78. doi:10.1016/j.colsurfa. 2004.07.026. <https://www.sciencedirect.com/science/article/pii/S092777570400531X> (2004).

R. Dias, M. Rosa, A. A. C. C. Pais, M. Miguel & B. Lindman. DNA-Surfactant Interactions. Compaction, Condensation, Decompaction and Phase Separation. J. Chin. Chem. Soc. 51. 447-469; IF: 0.879, Cited by 39. doi:10.1002/jccs.200400069. <https://onlinelibrary.wiley.com/doi/10.1002/jccs.200400069/abstract> (2004).

J. M. G. Sarragu ̧ca & A. A. C. C. Pais. Simulation of polyelectrolyte solutions. The density of bound ions. Chem. Phys. Lett. 398. 140-145; IF: 1.815, Cited by 13. doi:10.1016/j.cplett.2004.09.042. <http : / / www.sciencedirect.com/science/article/pii/S0009261404014265> (2004).

M. J. Tapia, H. D. Burrows, J. M. Garc ́ıa, F. Garc ́ıa & A. A. C. C. Pais. Lanthanide ion interaction with a crown ether methacrylic polymer, poly (1, 4, 7, 10-tetraoxacyclododecan-2-ylmethyl methacrylate), as seen by spectroscopic, calorimetric, and theoretical studies. Macromolecules 37. 856-862; IF: 5.835, Cited by 18. doi:10.1021/ma0353888. <https://pubs.acs.org/doi/abs/10.1021/ma0353888> (2004).

L. G. Arnaut, A. A. C. C. Pais, S. J. Formosinho & M. Barroso. Absolute rate calculations for atom abstractions by radicals: Energetic, structural and electronic factors. J. Am. Chem. Soc. 125.  5236-5246; IF: 13.858, Cited by 28. doi:10.1021/ja029298e. <https://pubs.acs.org/doi/ab/10.1021/ja029298e> (2003).

F. O. Costa, J. J. S. Sousa, A. A. C. C. Pais & S. J. Formosinho. Comparison of dissolution profiles of Ibuprofen pellets. J. Contr. Rel. 89. 199-212; IF: 7.786, Cited by 141. doi:10 . 1016 / s0168 - 3659(03 )00033-6. <https://www.sciencedirect.com/science/article/pii/S0168365903000336> (2003).

R. S. Dias, A. A. C. C. Pais, M. G. Miguel & B. Lindman. Modeling of DNA compaction by polycations. J. Chem. Phys 119. 8150-8157; IF:2.965, Cited by 74. doi:10.1063/1.1609985. <https://aip.scitation.org/doi/abs/10.1063/1.1609985> (2003).

M. Leitão, J. Canotilho, A. Sousa, A. A. C. C. Pais, A. Sousa & J.Simões Redinha. Infrared spectroscopy and the characterization of terfenadine crystallized from solvents. J. Therm. Anal. Calorim. 73. 763-774; IF: 1.953, Cited by 2. doi:10.1023/A:1025826329359. <https://link.springer.com/article/10.1023/A:1025826329359> (2003).

M. Miguel, A. A. C. C. Pais, R. S. Dias, C. Leal, M. Rosa & B. Lindman. DNA-cationic amphiphile interactions. Colloids Surf. A Physicochem. Eng. Asp. 228. 43-55; IF: 2.714, Cited by 72. doi:10.1016/S09277757(03)00334-0. <https://www.sciencedirect.com/science/article/pii/S0927775703003340> (2003).

J. M. G. Sarragu ̧ca, M. Skep ̈o, A. A. C. C. Pais & P. Linse. Structure of polyelectrolytes in 3:1 salt solutions. J. Chem. Phys. 119. 12621-12628; IF: 2.965, Cited by 42. doi:10.1063/1.1625367. <https://aip.scitation.org/doi/abs/10.1063/1.1625367> (2003).

A. F. Sousa, J. Canotilho, A. A. C. C. Pais, M. L. P. Leitão & J. S. Redinha. Molecular dynamics simulation of the terfenadine monomer and dimer, including solvent effects. Mol. Phys. 101. 871-879; IF: 1.870, Cited by 2. doi:10 . 1080 / 0026897031000075688. <https://www.tandfonline.com/doi/abs/10.1080/0026897031000075688?src=recsys&> (2003).

A. A. C. C. Pais, M. G. Mguel, P. Linse & B. Lindman. Polyelectrolytes confined to spherical cavities. J. Chem. Phys. 117. 1385-1394; IF: 2.965, Cited by 30. doi:10.1063/1.1483857. <https://aip.scitation.org/doi/abs/10.1063/1.1483857> (2002).

M. J. Tapia, H. D. Burrows, M. Emília D. G. Azenha, M. da Graca Miguel, A. A. C. C. Pais & J. M. G. Sarragu ̧ca. Cation association withsodium dodecyl sulfate micelles as seen by lanthanide luminescence. J. Phys. Chem. B 106. 6966-6972; IF: 3.177, Cited by 34. doi:10.1021/jp014083x. <https://pubs.acs.org/doi/abs/10.1021/jp014083x>(2002).

L. G. Arnaut, A. A. C. C. Pais & S. J. Formosinho. The intersecting-state model: a link between molecular spectroscopy and chemical reactivity. J. Mol. Struct. 563. 1-17; IF: 1.753, Cited by 20. doi:10.1016/S0022-2860(00)00785-7. <https://www.sciencedirect.com/science/article/pii/S0022286000007857> (2001).

A. A. C. C. Pais, A. Sousa, M. E. Eus ́ebio & J. S. Redinha. Solvation of alkane and alcohol molecules. Energy contributions. Phys. Chem. Chem.Phys. 3. 4001-4009; IF: 4.123, Cited by 29. doi:10.1039/b104981j. <https://pubs.rsc.org/en/content/articlelanding/2001/cp/b104981j#!divAbstract> (2001).

J. L. G. C. Pereira, A. A. C. C. Pais & J. S. Redinha. Maximum likelihood estimation with nonlinear regression in polarographic and potentiometric studies. Anal. Chim. Acta 433. 135-143; IF: 4.950, Cited by 3. doi:10 . 1016 / S0003 - 2670(00 ) 01320 - 9. <https://www.sciencedirect.com/science/article/pii/S0003267000013209> (2001).

A. A. C. C. Pais, J. L. G. C. Pereira & J. S. Redinha. Nonlinear regression in parameter estimation from polarographic signals. Comp. Chem. 24. 533-539; IF: 1.331, Cited by 5. doi:10.1016/S0097-8485(00)00061-9. <https://www.sciencedirect.com/science/article/pii/S0097848500000619> (2000).

Z. Freixa, M. M. Pereira, A. A. C. C. Pais & J. C. Bayon. Evidence of a rhodium catalytic species containing a bridging 1, 2-diphosphine in styrene hydroformylation. J. Chem. Soc., Dalton Trans. 3245-3251; IF:4.029, Cited by 13. doi:10.1039/A904019F. <https://pubs.rsc.org/en/Content/ArticleLanding / 1999 / DT / a904019f # !divAbstract> (1999).

A. A. C. C. Pais, L. G. Arnaut & S. J. Formosinho. Hydrogen-atom abstractions: a semi-empirical approach to reaction energetics, bond lengths and bond-orders. J. Chem. Soc., Perkin Trans. 2. 2577-2584, Cited by 20. doi:10.1039/A807265E. <https://pubs.rsc.org/en/Content/ArticleLanding/1998/P2/a807265e#!divAbstract> (1998).


Book chapters:

T. F. G. G. Cova, S. Cruz, P. Abreu, J. Marques, A. A. C. C. Pais & A. M. J. Valente. Aggregation of Cyclodextrins: Fundamental issues and applications. In Cyclodextrin - A Versatile Ingredient. doi: 10.5772/intechopen.73532, 2018;

T.F.G.G. Cova, J.S. Almeida, A.A.C.C. Pais e S.J. Formosinho Uma visão das culturas do mundo através da Ciência: o papel do conhecimento tácito in Interdisciplinaridade e Universidade, A. R. Amaro, A. Garrido e J. P. Avel as Nunes (coord.), p 71-95, Imp. U.C., 2016; 

Carla Vitorino, António Almeida, João Josá Sousa and Alberto Pais Crossing the Skin Barrier: A Development Strategy, in Simvastatin Delivery: Challenges and Opportunities, A.A.C.C. Pais, J.J. Sousa and C.S. Vitorino (eds.), p 61-91, Nova, 2015; 

J.S. Redinha, A.J. Lopes Jesus, A.A.C.C. Pais and J. A. S. Almeida Crystallization: From the Conformer to the Crystal, in Advanced Topics on Crystal Growth, Sukarno Olavo Ferreira (ed.), p 201-223, Intch, 2013; 

J. Barbosa, S. Ferreira, A. C. Pais, M.I.N. Silveira, F. Ramos Nitrofurans in Poultry: Use, Control and Residue Analysis, in Agricultural Research Updates. Volume 1, p 1-50, B. P. Hendricks (ed.), Nova, 2011; 

A.A.C.C. Pais and P. Linse Simulations of polyions: Compaction, adsorption onto surfaces, and confinement in DNA interactions with polymers and surfactants, R.S. Dias and B. Lindman (eds.), p 337-352, Wiley, Hoboken, 2008; 

J.A.S. Almeida, A.A.C.C. Pais e S.J. Formosinho O papel dos indicadores científicos na avaliação das marcas culturais na ciência europeia in Bibliotecas e arquivos jurídicos em mudança. Novas realidades, Revista da Faculdade de Direito de Lisboa, suplem. 2009; 

A.A.C.C. Pais Experimental design in Catalysis from theory to application. An integrated course, J.L. Figueiredo, M.M. Pereira and J. Faria (eds.), p 567-587, CUP, Coimbra, 2008; 

R.S. Dias, A.A.C.C. Pais, M.G.M. Miguel and B. Lindman, DNA compaction and decompaction: bulk and interfaces in Coloides e interfases, M. M. Velazquez and M. D. Merchan, (eds.), p 403-407, Universidad de Salamanca, Salamanca, 2005.